Cyclobenzaprine: Uses, Interactions, Mechanism of Action DrugBank Online
This is not a complete list ofFlexeril drug interactions. Elderly patients seem to tolerate cyclobenzaprine less and may develop hallucinations as well as significant anticholinergic side effects, such as sedation. The use of significant lower dosing schedules in elderly patients may be prudent.
It helps relieve pain, stiffness, and discomfort caused by strains, sprains, or injuries to your muscles. However, this medicine does not take the place of rest, exercise or physical therapy, or other treatment that your doctor may recommend for your medical problem. Cyclobenzaprine acts on the central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of this medicine’s side effects. The incidence of drowsiness, the most frequent adverse reaction, was similar with both drugs. In patients with CNS depression, early intubation is advised because of the potential for abrupt deterioration.
There are other drugs available to treat your condition. Talk with your doctor about other drug options that may work for you. As with all medications, the costs of cyclobenzaprine can vary. Cyclobenzaprine flexeril.live may be used as part of combination therapy. This means you may need to take it with other medications. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help.
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Therefore, this drug should only be used in pregnancy if clearly needed. Many insurance companies require prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription. It isn’t known exactly how this drug works to relax your muscles.
An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. Cyclobenzaprine oral tablet may cause drowsiness and dizziness. This is more likely to happen in the few hours after you take it. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medication affects you.
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Among the most dreaded toxicities linked with cyclical antidepressants, overdoses affect fast-acting sodium channels in the cardiac conduction system. Cyclical antidepressants block the cardiac sodium channel and cause prolongation of cardiac depolarization, which manifests as QRS widening on electrocardiograms. There is also evidence that cyclical antidepressants may decrease the seizure threshold by interfering with chloride conductance on the GABA receptor. For most patients, the recommended dose of FLEXERIL is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day.
Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body. In case of acute cyclobenzaprine overdose, emergency medicine physicians and triage nurses should stabilize the patient. If EKG demonstrates QRS prolongation, the clinician should initiate sodium bicarbonate therapy. In severe overdose, ventricular arrhythmias and seizures may require MICU-level of care under the supervision of a critical care physician. As discussed above, the clinician should consider contacting the poison control center in refractory cases. A psychiatrist consult is required for deliberate poisoning of cyclobenzaprine.
If you are not able to swallow the extended-release capsule whole, mix the contents of the capsule with applesauce. Eat the mixture right away and swallow without chewing. After you eat the mixture, take a drink, and swish and swallow to make sure that you have received all the medication. Since overdosage is often deliberate, patients may attempt suicide by other means during the recovery phase. FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants.
- Please be advised that this content is no longer actively maintained and may now contain outdated information.
- However, the dosage strength differs for humans and dogs, and dogs are at risk for addiction.
- Flexeril depresses the central nervous system, an effect some find desirable, which can lead to misuse.
- It is available in the form of tablets and extended-release capsules.
Protect the patient’s airway, establish an intravenous line and initiate gastric decontamination. Observation with cardiac monitoring and observation for signs of CNS or respiratory depression, hypotension, cardiac dysrhythmias and/or conduction blocks, and seizures is necessary. If signs of toxicity occur at any time during this period, extended monitoring is required. Monitoring of plasma drug levels should not guide management of the patient. Dialysis is probably of no value because of low plasma concentrations of the drug. As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment.
How was your experience with Flexeril?
Flexeril usually takes between 45 minutes to an hour to work after being ingested to show relaxation activity. It peaks at around 3 to 4 hours, and then the effects begin to wear off. This timeline is appropriate for an immediate-release formulation. In the case of an extended-release formulation, the effects last for up to 24 hours. However, the half-life of immediate-release cyclobenzaprine is 18 hours on average, with a range of 8-37 hours.